As Barcelona defeated Real Madrid, Franck Kessie scored a thrilling late winner to extend their La Liga lead to 12 points.
Ronald Araujo of Barcelona headed Vinicius Jr.'s cross into his own net to give Real the lead in El Clasico against the flow of play.
Raphinha's attempt was blocked, and Sergio Roberto's shot from right before halftime gave Barca the lead back.
Marco Asensio saw a late strike for Real ruled out for offside before Kessie scored the injury-time winner.
Both sides have 12 league matches remaining, and Barca are in a dominant position as they look to win the title for the first time since 2018-19.
Roberto said: "You can never say [the title] is over, but we have now gone 12 points clear, so it’s difficult for them."
"It’s down to us, and that’s the most important thing." I’m just glad to have helped the team with a goal. It was epic at the end, and I’m pleased for Franck to get the goal.
As Asensio appeared to have scored, but the goal was disallowed for offside, and the game turned in our favor. It's amazing to do so in front of our fans, and it feels much better when you win with a late goal.
Sergi Roberto equalized for Barcelona at the Nou Camp with his fourth La Liga goal of the season.
Reigning Spanish champions Real came into this game having beaten Liverpool 1-0 on Wednesday to complete a 6-2 aggregate victory to move into the Champions League quarter-finals.
Karim Benzema, who scored against the Reds, had the first shot of the match inside the opening minute but saw his effort from outside the penalty area well held by Marc-Andre ter Stegen.
But the visitors were then indebted to goalkeeper Thibaut Courtois, as he made excellent saves to keep out Robert Lewandowski’s well-struck 25-yard effort and Raphael’s header.
Real took a nine-minute lead, but Barcelona, the 26-time Spanish champions, had the better of the first half.
Andreas Christensen was unable to take two opportunities, and Raphal had a shot tipped over by Courtois before Roberto leveled in the 45th minute.
Lewandowski, the top scorer in La Liga with 15 goals, had a shot deflected just wide before Real substitute Rodrigo fired over at the other end in his first involvement.
Raphinha nearly won it in the 74th minute but was denied by another excellent Courtois save, while Lewandowski also shot into the side netting
Asensio had only been on the pitch for six minutes when he put the ball in the net for Real late on, but the goal was ruled out after a tight video assistant referee offside decision.
Substitute Kessie was then Barcelona’s hero in the 92nd minute, finishing after good work from Alejandro Balde.
Barcelona manager Xavi said: "The league is not decided, but it’s a huge win of course."
"I think we deserved the win, and we were better than Real Madrid; we created more opportunities."
Barcelona are next in action on April 1 with an away game at Elche before Real Madrid entertain Real Valladolid the following day.
